3,4-Diaminopyridine, 97%

Description

CAS: 54-96-6 | C5H7N3 | 109.132 g/mol

It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.

Solubility
Soluble in water (24 mg/ml at 20°C), alcohol. Slightly soluble in ether.

Notes
Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 54-96-6
• Molecular Formula: C5H7N3
• Molecular Weight (g/mol): 109.132
• MDL Number: MFCD00006401
• InChI Key: OYTKINVCDFNREN-UHFFFAOYSA-N
• Synonym: 3,4-diaminopyridine, amifampridine, 3,4-pyridinediamine, firdapse, diamino-3,4 pyridine, 4,5-diaminopyridine, 3,4-dap, amifampridin, zenas, pyridine, 3,4-diamino
• PubChem CID: 5918
• IUPAC Name: pyridine-3,4-diamine
• SMILES: C1=CN=CC(=C1N)N

• Melting Point: 217°C to 220°C
• Flash Point: 240°C (464°F)
• Odor: Unpleasant
• Quantity: 1 g
• UN Number: UN2811
• Beilstein: 110232
• Merck Index: 14,2986
• Solubility Information: Soluble in water (24mg/ml at 20°C),alcohol. Slightly soluble in ether.
• Formula Weight: 109.13
• Percent Purity: ≥98%
• Chemical Name or Material: 3,4-Diaminopyridine

Safety and Handling

Hazard Category	H300+H330-H311-H315-H318-H335
Hazard Statement	GHS H Statement H300-H330-H312-H319 Fatal if swallowed. Fatal if inhaled. Harmful in contact with skin. Causes serious eye irritation.
Precautionary Statement	P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P361-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: II; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	200-220-9
RTECSNumber	US7600000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only