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3-Methylcytosine (3-mC) Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501994144
Encompass
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100 μL
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50-199-4144 10 μL
50-199-4143 100 μL
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Catalog No. 50-199-4144 Supplier Active Motif Supplier No. 61180
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Description

Rabbit Polyclonal Antibody

3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.

Specifications

Antigen 3-Methylcytosine (3-mC)
Applications Dot Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias 3mc; 3-mC; 3-meC; 3-Methyl-cytosine; C5H7NO3
Host Species Rabbit
Immunogen This 3-methylcytosine antibody was raised against 3-methylcytidine conjugated to kLH and recognizes 3-methylcytosine .
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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