4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

Description

CAS: 30827-99-7 | C8H11ClFNO2S | 239.689 g/mol

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Solubility
Soluble in water 50 mg/mL or 100% ethanol.

Notes
Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Specifications

Chemical Identifiers

• CAS: 30827-99-7
• Molecular Formula: C8H11ClFNO2S
• Molecular Weight (g/mol): 239.689
• MDL Number: MFCD00132962
• InChI Key: WRDABNWSWOHGMS-UHFFFAOYSA-N
• Synonym: 4-2-aminoethyl benzenesulfonyl fluoride hydrochloride, aebsf, aebsf hydrochloride, pefabloc sc, aebsf hcl, pefabloc, 4-2-aminoethyl benzene-1-sulfonyl fluoride hydrochloride, aebsf, hydrochloride, benzenesulfonyl fluoride, 4-2-aminoethyl-, hydrochloride, 4-2-aminoethyl benzenesulfonylfluoride hydrochloride
• PubChem CID: 186136
• IUPAC Name: 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
• SMILES: C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

• Melting Point: ∼184°C (decomposition)
• Quantity: 250 mg
• UN Number: UN3261
• Beilstein: 7604627
• Sensitivity: Moisture sensitive
• Solubility Information: Soluble in water 50mg/mL or 100% ethanol.
• Formula Weight: 239.69
• Percent Purity: 97%
• Chemical Name or Material: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

Safety and Handling

Hazard Category	H314-H500
Hazard Statement	GHS H Statement H314-H318 Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statement	P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c
DOTInformation	Hazard Class: 8; Packaging Group: III
TSCA	No
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only