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AdipoGen 5-Fluorocytosine

Supplier: AdipoGen CDXF0077G005

Chemical. CAS 2022-85-7. Formula C4H4FN3O. MW 129.09. Synthetic Fluorinated pyrimidine analog. Antimycotic prodrug that is converted by cytosine deaminase to 5-fluorouracil a widely used cytotoxic drug and further metabolized to fluorinated ribo- and deoxyribonucleotides. Inhibits DNA and RNA synthesis and interfers with ribosomal protein synthesis. Displays antifungal and antitumor activity. Lately with the development of gene therapy, it has been introduced as a prodrug in combination with the cytosine deaminase suicide gene as antitumor compound, significantly improving survival and reducing tumor size in selected tumors.
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