Thermo Scientific Chemicals 5-Fluorouracil, 99%

Catalog No.	Quantity	Packaging
AC228440010	1 g	Glass bottle
AC228440050	5 g	Glass bottle
AC228440250	25 g	Glass bottle
AC228441000	100 g	Glass bottle

Catalog No. AC228440010 Supplier Thermo Scientific Chemicals Supplier No. 228440010

Description

5-Fluorouracil, CAS # 51-21-8, is an analogue base composed of uracil with a position 5 hydrogen fluorine substitution. | CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• 5-Fluorouracil is an antimetabolite and antineoplastic that prevents DNA synthesis by blocking conversion of deoxyuridylic acid

• 5-Fluorouracil can replace uracil in RNA and prevent protein synthesis and cell growth

Applications

• 5-Fluorouracil can be used for laboratory research on tumor growth and immunosuppression

• 5-Fluorouracil may also be appropriate for laboratory studies of neurotoxicity, cell lysis, and DNA damage

Specifications

Chemical Identifiers

• CAS: 51-21-8
• Molecular Formula: C4H3FN2O2
• Molecular Weight (g/mol): 130.08
• MDL Number: MFCD00006018
• InChI Key: GHASVSINZRGABV-UHFFFAOYSA-N
• Synonym: 5-fluorouracil, fluorouracil, 5-fu, fluoroplex, adrucil, efudex, carac, fluracil, fluoroblastin, kecimeton
• PubChem CID: 3385
• ChEBI: CHEBI:46345
• IUPAC Name: 5-fluoro-1H-pyrimidine-2,4-dione
• SMILES: FC1=CNC(=O)NC1=O

• Melting Point: 278.0°C to 282.0°C
• Color: White
• Boiling Point: 190.0°C to 200.0°C (0.1 mmHg)
• Loss on Drying: 0.5% (80°C, 4 hrs) (in vacuum) max.
• Infrared Spectrum: Authentic
• Assay Percent Range: 99%
• Packaging: Glass bottle
• Quantity: 1 g
• Beilstein: 24,IV,1229
• Merck Index: 15,4213
• Solubility Information: Solubility in water: 12.2g/L (20°C). Other solubilities: 2.9g/L (20°C) in ethanol,readily soluble in aqueous alkali solutions,soluble in dmso
• Formula Weight: 130.08
• Percent Purity: 99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: 5-Fluorouracil

Safety and Handling

Hazard Category	GHS Signal Word: Danger
Hazard Statement	GHS H Statement Suspected of causing genetic defects. Suspected of damaging the unborn child. Toxic if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes serious eye irritation. Causes skin irri
Precautionary Statement	GHS P Statement Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF INHALED: Remove victim to fresh air and keep at rest in a position comforta
EINECSNumber	200-085-6

SDS

RUO – Research Use Only