5-Fluorouracil, 99%

Description

CAS: 51-21-8 | C4H3FN2O2 | 130.08 g/mol

5-Fluorouracil is used as an antitumor agent in the treatment of anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers. It finds application as a suicide inhibitor due to its irreversible inhibition of thymidylate synthase. It is also used in the treatment of actinic keratoses and bowen's disease. Further, it serves as a potent antineoplastic agent in clinical use. In addition to this, it acts as a DNA synthesis inhibitor.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethylformamide, dimethyl sulfoxide, methanol, hot water, ammonium hydroxide, sodium hydroxide, ethanol and water.

Notes
Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 51-21-8
• Molecular Formula: C4H3FN2O2
• Molecular Weight (g/mol): 130.08
• MDL Number: MFCD00006018
• InChI Key: GHASVSINZRGABV-UHFFFAOYSA-N
• Synonym: 5-fluorouracil, fluorouracil, 5-fu, fluoroplex, adrucil, efudex, carac, fluracil, fluoroblastin, kecimeton
• PubChem CID: 3385
• ChEBI: CHEBI:46345
• IUPAC Name: 5-fluoro-1H-pyrimidine-2,4-dione
• SMILES: FC1=CNC(=O)NC1=O

• Melting Point: ∽282°C (decomposition)
• Assay Percent Range: 99%
• Quantity: 5 g
• UN Number: UN2811
• Beilstein: 127172
• Sensitivity: Light sensitive
• Merck Index: 14,4181
• Solubility Information: Soluble in dimethylformamide,dimethyl sulfoxide,methanol,hot water,ammonium hydroxide,sodium hydroxide,ethanol and water.
• Formula Weight: 130.08
• Percent Purity: 99%
• Chemical Name or Material: 5-Fluorouracil

Safety and Handling

Hazard Category	H301-H312+H332-H315-H319-H335-H341-H361d
Hazard Statement	GHS H Statement H360-H341-H373-H302
Precautionary Statement	P201-P202-P261-P264b-P270-P271-P280i-P281-P301+P310-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	200-085-6
RTECSNumber	YR0350000
TSCA	Yes
storageNote1	Air Sensitive
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only