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Invitrogen™ 5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody (GT513)
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Catalog No. PIMA542319
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100 μL
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PIMA542319 100 μL
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Catalog No. PIMA542319 Supplier Invitrogen™ Supplier No. MA542319
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Description

Mouse Monoclonal Antibody

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
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Specifications

Antigen 5-Hydroxymethylcytosine (5-hmC)
Applications Dot Blot, Methylated DNA Immunoprecipitation
Classification Monoclonal
Clone GT513
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias 5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2
Host Species Mouse
Immunogen 5-Hydroxymethylcytosine/5-hmC.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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