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5-Hydroxymethylcytosine (5-hmC) Polyclonal Antibody, Active Motif™
SDP

Rabbit Polyclonal Antibody

$144.60 - $572.38

Specifications

Antigen 5-Hydroxymethylcytosine (5-hmC)
Concentration Conc. Not Determined
Applications Dot Blot, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
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Products 3
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-4114
SDP
Encompass
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Active Motif
39770
10 μL
Each for $144.60
Only null left
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50-199-4115
SDP
Encompass
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Active Motif
39069
50 μL
Each for $325.35
Only null left
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50-199-4113
SDP
Encompass
View Documents
Active Motif
39769
100 μL
Each for $572.38
Only null left
Add to Cart
 
Description

Description

5-hydroxymethylcytosine (5-hmC) has been recently discovered in mammalian DNA. 5-hmC results from the enzymatic conversion of 5-methylcytosine into 5-hydroxymethylcytosine by the TET family of oxygenases. Initially, the 5-hmC base had been identified in Purkinje neurons, in granule cells and embryonic stem cells where it is present at high levels (up to 0,6% of total nucleotides in Purkinje cells). A recent report indicates that 5-hmC is also abundant in brain tissue, especially in areas that are associated with higher cognitive functions.Early evidence suggests that 5-hmC may represent an intermediate in a new pathway which demethylates DNA, converting 5-mC to cytosine. Although its precise role has still to be shown, recent results indicate, however, that 5-hmC may play important roles distinct from 5-mC. This may open up entirely new perspectives in epigenetic studies.
Specifications

Specifications

5-Hydroxymethylcytosine (5-hmC)
Dot Blot, Immunoprecipitation
Unconjugated
Rabbit
Human, Mouse
5hmc; 5-hmc; 5-HydroxymethylCytidine; C5H7N3O2
IgG
-20°C, Avoid Freeze/Thaw Cycles
Conc. Not Determined
Polyclonal
Liquid
RUO
whole serum with 30% glycerol and 0.035% sodium azide; pH
This 5-Hydroxymethylcytosine antibody was raised against 5-hydroxymethylcytidine conjugated to kLH and recognizes 5-hydroxymethylcytosine.
Primary
Antibody
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