5 Lipoxygenase Mouse anti-Human, Porcine, Clone: 3B1B7, Proteintech

Catalog No.	Quantity
50-173-6758	150 μL

Catalog No. 50-173-6758 Supplier Proteintech Group Inc Supplier No. 663261IG150UL

Description

Mouse Monoclonal Antibody

The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LT) (Funk, 2001). Overproduction of LT contributes to several diseases, most notably chronic inflammatory diseases, including asthma (Drazen et al., 1994), fibrosis (Wilborn et al., 1996) and atherosclerosis (Dwyer et al., 2004). Recent work has demonstrated that the activity of 5-LO is regulated by PKA phosphorylation of serine-523 in 5-LO (Luo et al., 2004). Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, then, could contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO is thus likely to provide a valuable toll for studies of the role of 5-LO regulation in diseases such as asthma, fibrosis and atherosclerosis.

Specifications

• Antigen: 5 Lipoxygenase
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 3B1B7
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: ALOX5
• Gene Accession No.: P09917
• Gene Alias: 5 lipoxygenase, 5 LO, 5 LOX, 5LPG, ALOX5, arachidonate 5 lipoxygenase, LOG5
• Gene Symbols: ALOX5
• Host Species: Mouse
• Immunogen: 5 Lipoxygenase Fusion Protein Ag18168
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100156205, 240
• Target Species: Human, Pig
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a