5-Methoxy-2-methylindole, 99+%, Thermo Scientific Chemicals

Description

CAS: 1076-74-0 | C10H11NO | 161.20 g/mol

It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is employed as a reactant in preparation of indolylquinoxalines by condensation reactions, reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation, reactant in arylation reactions using a palladium acetate catalyst, reactant in enantioselective Friedel-Crafts alkylation and reactant in stereoselective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation. As an indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid anti-inflammatory synthesis.

Solubility
Soluble in methanol (very faint turbidity.)

Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Specifications

Chemical Identifiers

• CAS: 1076-74-0
• Molecular Formula: C10H11NO
• Molecular Weight (g/mol): 161.20
• MDL Number: MFCD00005620
• InChI Key: VSWGLJOQFUMFOQ-UHFFFAOYSA-N
• Synonym: 5-methoxy-2-methylindole, 2-methyl-5-methoxyindole, 1h-indole, 5-methoxy-2-methyl, indole, 5-methoxy-2-methyl, pubchem7236, acmc-1buiu, maybridge1_002343, 5-methoxy-2 methylindole, 2-methyl-5-methoxylindole, 2-methyl-5-methoxy indole
• PubChem CID: 70642
• IUPAC Name: 5-methoxy-2-methyl-1H-indole
• SMILES: COC1=CC=C2NC(C)=CC2=C1

• Melting Point: 85°C to 88°C
• Quantity: 25 g
• Sensitivity: Light sensitive
• Solubility Information: Soluble in methanol (very faint turbidity.)
• Formula Weight: 161.2
• Percent Purity: ≥99%
• Chemical Name or Material: 5-Methoxy-2-methylindole

Safety and Handling

Hazard Category	H315-H319-H335
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	214-066-5
TSCA	No
Recommended Storage	Keep cold

SDS

RUO – Research Use Only