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Invitrogen™ 5-Methylcytosine Monoclonal Antibody (GT4111)
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Catalog No. PIMA531475
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100 μL
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Catalog No. Quantity
PIMA531475 100 μL
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Catalog No. PIMA531475 Supplier Invitrogen™ Supplier No. MA531475
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Description

Mouse Monoclonal Antibody

Keep as concentrated solution. Positive Control: SH-SY5Y genomic DNA. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Methylation of DNA cytosine bases plays important roles in the regulation of gene transcription. It has been estimated that 60 to 90% of the cytosines in CpG dinucleotides are methylated. An increase in methyl-CpG correlates with transcriptional silencing for the whole chromosome especially in developmentally regulated genes. Methylation is believed to lead to transcriptional silencing by multiple mechanisms including alteration of transcription factor binding to promoters and alteration in chromatin structure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen 5-Methylcytosine
Applications Dot Blot, Immunohistochemistry (Frozen), Immunohistochemistry (Free Floating), Immunohistochemistry (Paraffin), Immunomicroscopy, Methylated DNA Immunoprecipitation
Classification Monoclonal
Clone GT4111
Concentration 1.7 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias 5mc; 5-mC; 5-meC; 5-Methyl-cytosine; C5H7NO3
Host Species Mouse
Immunogen The immunogen used to generate this antibody corresponds to 5-Methylcytosine/5-mC.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
Target Molecule Chemical
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