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Cytiva 5 mL HiTrap™ MabSelect™ SuRe 70 Column
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Quantity:
1 Column
5 Columns
Description
MabSelect™ SuRe 70 protein A resin with high dynamic binding capacity (DBC), enables highly cost-efficient capture of monoclonal antibodies (mAbs). The resin uses the well-established SuRe protein A ligand with good alkaline stability providing stable processing of mAbs.
- Cost-efficient at low resin utilization, such as in clinical manufacturing.
- Highest DBC of any of our MabSelect SuRe™ resins
- Alkaline-stable, well-established protein A ligand, from the MabSelect SuRe resin, is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH.
- Bed volume: 5 mL
- Bed dimensions: 16 x 25 mm
- Bed height: 25 mm
- Column i.d.: 16 mm
- Excellent for use in short bed heights and rapid resin cycling mode to further improve productivity in protein A step.
DBC at different residence times
- The MabSelect™ SuRe 70 resin is based on a high-flow agarose base matrix with an average bead size of 50 μm.
- The optimized porosity enables a fast uptake of mAb, and the DBC is less dependent on residence time (RT) compared to other resins (e.g., MabSelect SuRe™ LX and MabSelect PrismA™ resins).
- The DBC for trastuzumab is higher than 70 g/L in a well-packed column at 6 min RT.
Alkaline-stable Protein A ligand
- As native protein A is sensitive to alkaline conditions, the ligand in MabSelect™ SuRe 70 resin, also used in the MabSelect SuRe™ resin, has been stabilized by engineering one of the IgG-binding domains of protein A.
- The MabSelect™ SuRe 70 resin is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH without performance loss.
Formats
- MabSelect™ SuRe 70 resin is available as bulk resin in 25 mL, 200 mL, 1 L, 5 L, and 10 L containers.
- The resin can be ordered in pre-packed column formats such as HiTrap™ columns (1 and 5 mL), HiScreen™ columns, and on request as production scale ReadyToProcess™ columns.
- These formats enable use from lab-scale to commercial-scale manufacturing.
Cytiva's mAb toolbox
- Process volumes, number of batches, target molecule, impurity profile, and cleaning protocols influence which chromatography resin will be most cost-efficient and productive in a given application.
- Cytiva can support you in a discussion about how to set up your process and to make your process more cost efficient.
- And with every Cytiva resin you choose, you have Cytiva quality, an extensive security of supply program, and expertise to go along with it.

Specifications
Specifications
Product Type | Column |
Flow Rate | < 20 mL/min. |
For Use With (Application) | Antibody Affinity Chromatography |
Quantity | 1 Column |
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