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Apexbio Technology LLC WP1066 857064-38-1 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A41405.1

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WP1066 (CAS 857064-38-1) is a small molecule analog of AG490 and functions primarily as an inhibitor of Janus kinase 2 (JAK2) It disrupts JAK2 signaling by reducing phosphorylation and promoting degradation of the JAK2 protein thereby inhibiting downstream STAT3/STAT5 transcription factors and the phosphoinositide-3 kinase pathway WP1066 has demonstrated antiproliferative and pro-apoptotic activity in models of acute myeloid leukemia (AML) including patient-derived AML cells and AML cell lines (OCIM2 K562) Additionally WP1066 shows inhibitory effects against tumor growth and angiogenesis in renal cell carcinoma (RCC) model systems highlighting its potential for hematologic cancers and RCC therapeutic research

Catalog No. 50-000-61424


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