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Apexbio Technology LLC AZD0156(Synonyms: AZD-0156, AZD0156 ATM inhibitor, ATM kinase inhibitor AZD0156, 1821428-35-6, ATM kinase inhibitor, AZD0156 inhibitor), 5mg, CAS: 1821428-35-6.
Supplier: Apexbio Technology LLC B78225
AZD0156 (CAS number 1821428-35-6) is an orally bioavailable potent and selective small-molecule inhibitor of ataxia telangiectasia mutated (ATM) kinase a serine/threonine kinase within the phosphatidylinositol 3-kinase-related kinase (PIKK) family ATM kinase contributes critically to DNA damage response signaling activated by DNA double-strand breaks thus facilitating DNA repair checkpoint control genomic stability and cell fate decisions AZD0156 demonstrates sub-nanomolar inhibitory potency against cellular ATM signaling and exhibits over 1000-fold selectivity relative to other PIKK enzymes In preclinical models oral AZD0156 administration potentiates antitumor responses induced by double-strand break-generating agents Currently AZD0156 is undergoing early clinical trials assessing safety and preliminary efficacy for advanced cancers
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