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Leica Biosystems 7ml Cytokeratin 20 Bond RTU Pr
Supplier: Leica Biosystems PA0022U

Antigen BackgroundCytokeratin 2 has been demonstrated to be almost entirely confined to the gastric and intestinal epithelium, urothelium and Merkel cells of the skin. Cytokeratin 2 is less acidic than other type I cytokeratins and is of interest due to its restricted tissue expression. In normal tissue, cytokeratin 2 is expressed in intestinal epithelium, gastric foveolar epithelium, a number of endocrine cells in the upper portions of the pyloric glands, urothelium and Merkel cells in epidermis. In tumors it is reported, there is a marked difference in the expression of cytokeratin 2 within different carcinomas. Neoplasms expressing cytokeratin 2 are derived from normal epithelia which themselves expressed cytokeratin 2. Colorectal carcinomas consistently express cytokeratin 2, while gastric adenocarcinomas express cytokeratin 2 to a lesser degree. Adenocarcinomas of the gall bladder and bile duct, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, Merkel cell tu
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