Leica Biosystems 7ml Factor XIIIa Bond RTU Prim

Supplier:  Leica Biosystems PA0449U

Antigen BackgroundFactor XIIIa, also known as fibrinoligase and fibrin-stabilizing factor, is the last enzyme generated in the blood coagulation cascade. It is a Ca2+-dependent transglutaminase or transamidating enzyme which forms intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules resulting in the mechanical stabilization of the fibrin clot and its resistance to proteolysis. Factor XIIIa may also function to stabilize cell surface molecules and membranes. Ca2+-dependent trans-glutaminases with thiol active centers are widespread in animal tissues and have been associated with cell proliferation, embryonic development and growth through the proliferation of mammary stroma and epithelial elements. Normal mammary stroma, like most collagenous connective tissue contains resident populations of CD34 positive dendritic interstitial cells and scattered Factor XIIIa positive collagen-associated dendrophages. Factor XIIIa has been examined to determine its expres

Catalog No. 50-255-2080