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  6. 8-Chloroadenosine, Tocris Bioscience™

8-Chloroadenosine, Tocris Bioscience™

Catalog No. 443650
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Catalog No. Quantity
44-365-0 50 mg
44-361-0 10 mg
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Catalog No. 44-365-0 Supplier R&D Systems Supplier No. 4436/50
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Description

Cytotoxic nucleoside analog; inhibits RNA synthesis

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Chemical Identifiers

CAS 34408-14-5
Molecular Formula C10H12ClN5O4
Molecular Weight (g/mol) 301.687
InChI Key MHDPPLULTMGBSI-FTWQFJAYSA-N
Synonym 8-chloroade-nosine
PubChem CID 13009312
IUPAC Name (2R,3R,4R,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
SMILES C1=NC2=C(C(=N1)N)N=C(N2C3C(C(C(O3)CO)O)O)Cl

Specifications

Quantity 50 mg
Formula Weight 301.69
Percent Purity >98%
Chemical Name or Material 8-Chloroadenosine

Safety and Handling

Recommended Storage Store at -20°C
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