Sigma Aldrich Pdph (3-(2-Pyridyldithio)Propionyl Hydrazide)

Catalog No.	Quantity
80-348-050MG	50 mg

Catalog No. 80-348-050MG Supplier Sigma Aldrich Supplier No. 80348050MG

Description

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The PDPH is a heterobifunctional crosslinker containing sulfhydryl-reactive pyridyldithiol and carbonyl-reactive hydrazide moieties. Pyridyldithiols react with free sulfhydryls (-SH) to form disulfide bonds. Hydrazide groups react with carbonyls (aldehydes and ketones) to form stable hydrazone bonds. Aldehyde groups can be created by periodate-oxidation of sialic acid and other sugar components of glycoprotein polysaccharides. Thus, PDPH is useful for conjugating glycoproteins and sulfhydryl-containing peptides or proteins. Likewise, PDPH is useful as a sulfhydryl-addition reagent for glycoproteins and other carbohydrates; after reaction of the hydrazide to an oxidized carbohydrate, the pyridyldithiol group can be cleaved by a reducing agent to expose a sulfhydryl group. Yet another application for PDPH is to react the primary amine of the hydrazide moiety to a carboxyl group using the crosslinker EDC.

Specifications

• Molecular Formula: C31H47ClNRh
• Linear Formula: C31H47ClNRh
• Quantity: 50 mg
• Synonym: [2-[2,6-bis(1-methylethyl)phenyl]-3,3-dimethyl-2-azaspiro[4.5]dec-1-ylidene]chloro[(1,2,5,6-eta)-1,5-cyclooctadiene]Rhodium
• Molecular Weight (g/mol): 572.07 g/mol