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  8. A 839977, Tocris Bioscience™

A 839977, Tocris Bioscience™

Catalog No. 423210
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Catalog No. Quantity
42-3210 10 mg
42-325-0 50 mg
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Catalog No. 42-3210 Supplier R&D Systems Supplier No. 4232/10
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Description

Potent P2X7 antagonist

Potent P2X7 antagonist; blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively). Displays antinociceptive effects in rat and mice models of inflammatory pain. CNS penetrant.

Chemical Identifiers

CAS 870061-27-1
Molecular Formula C19H14Cl2N6O
Molecular Weight (g/mol) 413.262
InChI Key GMVNBKZQJFRFAR-UHFFFAOYSA-N
Synonym 1-2,3-dichlorophenyl-n-2-pyridin-2-yloxy phenyl methyl-1,2,3,4-tetrazol-5-amine, d0m0xc, 1-2,3-dichlorophenyl-n-2-pyridin-2-yloxy benzyl-1h-tetrazol-5-amine, 1-2,3-dichlorophenyl-n-2-2-pyridinyloxy phenyl methyl-1h-tetrazol-5-amine, 1-2,3-dichlorophenyl-n-2-pyridin-2-yloxy phenyl methyl-1h-1,2,3,4-tetrazol-5-amine
PubChem CID 53325875
IUPAC Name 1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine
SMILES C1=CC=C(C(=C1)CNC2=NN=NN2C3=C(C(=CC=C3)Cl)Cl)OC4=CC=CC=N4

Specifications

Quantity 10 mg
Formula Weight 413.26
Percent Purity >98%
Chemical Name or Material A 839977

Safety and Handling

Recommended Storage Store at +4°C
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