A4GNT Mouse anti-Human, Clone: OTI2H9, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526433
DescriptionAlpha 1,4-N-acetylflucosaminyltransferase (alpha4Gn-T) mediates the biosynthesis of mucin type glycoprotein (O-glycan). alpha4Gn-T acts as the key enzyme for the formation of the unique glycan GlcNAcalpha1-4Galbeta1-R, and most efficiently transfers N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. alpha4Gn-T is a single-pass type II membrane protein associated with the Golgi apparatus and contains the conserved DXD motif involved in catalytic activity. It is expressed in stomach and pancreas, as well as in gastric cancer cells. alpha4Gn-T is not expressed in peripheral blood cells, making it a useful biomarker for pancreatic cancer. alpha4Gn-T and Mucin 6 expression is upregulated in the gastric mucosa of H. pylori infected patients, which suggest the involvement of alpha4Gn-T in defense against H. pylori infection.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Alpha-1;4-N-acetylglucosaminyltransferase; alpha4GnT; A4GNT; GnTalpha4; alpha4 GnT|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 121-340 of A4GNT produced in E.coli|
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