ABAT Mouse anti-Human, Clone: UMAB178, liquid, UltraMAB™

Catalog No.	Quantity
50-168-5266	100 μL

Catalog No. 50-168-5266 Supplier OriGene Supplier No. UM800070

Description

Mouse Monoclonal Antibody

ABAT (4-aminobutyrate aminotransferase) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codomit alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Specifications

• Antigen: ABAT
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: UMAB178
• Concentration: 0.5-1.0 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: ABAT
• Gene Accession No.: P80404
• Gene Alias: GABA-AT, GABAT, NPD009
• Gene Symbols: ABAT
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 29-323 of human ABAT produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1