ABAT Mouse anti-Human, Clone: UMAB179, lyophilized, UltraMAB™

Catalog No.	Quantity
50-168-5269	100 μg

Catalog No. 50-168-5269 Supplier OriGene Supplier No. UM800071CF

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

ABAT (4-aminobutyrate aminotransferase) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codomit alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Specifications

• Antigen: ABAT
• Applications: Immunohistochemistry (Paraffin), Peptide Array
• Classification: Monoclonal
• Clone: UMAB179
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: ABAT
• Gene Accession No.: P80404
• Gene Alias: GABA-AT, GABAT, NPD009
• Gene Symbols: ABAT
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 29-323 of human ABAT produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1