Invitrogen™ ABCA7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559624

Catalog No. PIPA559624

Description

Immunogen sequence: VNRTFEELTL LRDVREVWEM LGPRIFTFMN DSSNVAMLQR LLQMQDEGRR QPRPGGRDHM EALRSFLDPG SGGYSWQDAH ADVGHL Highest antigen sequence identity to the following orthologs: Mouse - 62%, Rat - 60%.

ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

Specifications

• Antigen: ABCA7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Abca7
• Gene Alias: ABC 1 antibody; ABC Transporter 1; ABC1; ABC1 antibody; Abc51; Abca7; ABCA-SSN; ABCX; AD9; ATP binding cassette subfamily A member 7; ATP-binding cassette sub-family A member 7; ATP-binding cassette sub-family A member 7; LOW QUALITY PROTEIN: ATP-binding cassette sub-family A member 7; ATP-binding cassette, subfamily A (ABC1), member 7; ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette, sub-family A, member 7; autoantigen SS-N; CERP; CERP antibody; EC 2.2.1.1; EC 3.6.3; EC 3.6.3.41; FLJ40025; Macrophage ABC transporter; Phospholipid-transporting ATPase ABCA7; phospholipid-transporting ATPase ABCA7; ATP-binding cassette sub-family A member 7
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10347
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IZY2
• Gene Symbols: Abca7
• Immunogen: Recombinant protein corresponding to Human ABCA7. Recombinant protein control fragment (Product #RP-98889).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG