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Eurofins Discoverx ABT-737, 5 mg. (92-1151)
Supplier: Eurofins Discoverx 921151

ABT-737 is a small molecule BH3 mimetic inhibitor of the anti-apoptotic members of the BCL-2 family, selective for BCL-2, BCL-XL, and BCL-W (EC50=78.7, 30.3, and 197.8 nM, respectively). Developed by AbbVie, it failed in clinical trials due to toxicity issues, but was proven efficacious with various radiation therapies in triggering apoptosis in cancer cells and xenografts. Provided as 5 mg of dry powder. These highly purified, pre-validated control ligands have been used to qualify our InCELL Hunter, PathHunter and cAMP Hunter cell lines as well as our Assay Ready Kits. Ligands are conveniently supplied with a recommended reconstitution buffer. For detailed information and product-specific datasheet, visit www.discoverx.com/ligands.
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