ACAP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 201351AP150UL
DescriptionACAP1, also known as Centaurin-beta-1 (CENTB1), is a 740 amino acid containing transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain and a PH domain that binds to phospholipids. ACAP1, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6), is required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. It mediates CENTB1-binding to phosphatidylinositol 3,5-bisphosphate (PIP2) or phosphatidylinositol 3,4,5-trisphosphate (PIP3) containing membranes. Along with ACAP2, ACAP1 is recruited to platelet-derived growth factor (PDGF) induced dorsal membrane ruffles in NIH 3T3 mouse fibroblasts, while over expression inhibited ruffle formation. It is widely expressed in most tissues with high expression in lung and spleen and low expression in heart, kidney, liver and pancreas.
|ACAP1, Centaurin beta 1, CENTB1, Cnt b1, KIAA0050|
|Antigen Affinity Chromatography|
|216859, 287443, 9744|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|ACAP1 Fusion Protein Ag14068|
|Human, Mouse, Rat|
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