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ACAP2 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501568311
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50-156-8311 20 μL
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Catalog No. 50-156-8311 Supplier Bethyl Laboratories, Inc Supplier No. A304656AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat and Rabbit

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.

Specifications

Antigen ACAP2
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene ACAP2
Gene Accession No. Q15057, Q6ZQK5
Gene Alias ACAP2; CENTB2; centaurin, beta 2; CNT-B2; KIAA0041; centaurin beta2; Arf GAP with coiled coil, ANK repeat and PH domains 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Gene Symbols Acap2
Host Species Rabbit
Immunogen Between 728 and 778
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23527, 78618
Target Species Human, Mouse
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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