ACBD3 Mouse anti-Human, Mouse, Rat, Clone: OTI1B5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF504892

Catalog No. 50-166-3228

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintece of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.

Specifications

• Antigen: ACBD3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ACBD3
• Gene Alias: GCP60, GOCAP1, GOLPH1, PAP7
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170760, 289312, 64746
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1B5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q7TNY6, Q8BMP6, Q9H3P7
• Gene Symbols: Acbd3
• Immunogen: Full length human recombit protein of human ACBD3 produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1