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ACBD3 Mouse anti-Human, Mouse, Rat, Clone: OTI1B5, lyophilized, TrueMAB™
SDP

Catalog No. 501663228
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50-166-3228 100 μg
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Catalog No. 50-166-3228 Supplier OriGene Supplier No. CF504892
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintece of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.

Specifications

Antigen ACBD3
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1B5
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene ACBD3
Gene Accession No. Q7TNY6, Q8BMP6, Q9H3P7
Gene Alias GCP60, GOCAP1, GOLPH1, PAP7
Gene Symbols Acbd3
Host Species Mouse
Immunogen Full length human recombit protein of human ACBD3 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170760, 289312, 64746
Target Species Human, Mouse, Rat
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG1
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