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Invitrogen™ ACE2 Monoclonal Antibody (CL4035)
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Catalog No. PIMA531395
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100 μL
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PIMA531395 100 μL
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Catalog No. PIMA531395 Supplier Invitrogen™ Supplier No. MA531395
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Description

Mouse Monoclonal Antibody

Immunogen sequence: MSSSSWLLLS LVAVTAAQST IEEQAKTFLD KFNHEAEDLF YQSSLASWNY NTNITEENVQ NMNNAGDKWS AFLKEQSTLA QMYPLQEIQN LTVKLQLQAL QQNGSSVLSE D Highest antigen sequence indentity to the following orthologs: Rat - 46%, Mouse - 74%.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACE2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CL4035
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ACE2
Gene Accession No. Q9BYF1
Gene Alias 2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885
Gene Symbols ACE2
Host Species Mouse
Immunogen Recombinant protein fragment of Human ACE2 (Product #RP-91894)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59272
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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