Invitrogen™ Acetylcholinesterase Monoclonal Antibody (HR2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3042

Catalog No. MA3042

Description

MA3-042 detects acetylcholinesterase (AChE) from human, mouse, rabbit, guinea pig, bovine and cat tissues. This antibody does not cross react with rat or frog AChE, and does not detect butyrylcholinesterase (BChE). MA3-042 has been successfully used in immunohistochemistry, immunoprecipitation and ELISA procedures. This antibody cannot be used in Western blot to detect AChE. Immunohistochemical staining of AChE in human brain samples with MA3-042 results in staining of nerve fibers and terminals. The MA3-042 antigen is purified human cerebellar acetylcholinesterase.

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. The Protein is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.

Specifications

• Antigen: Acetylcholinesterase
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: O62763, P21836, P22303, P23795
• Gene Symbols: ACE-1, ACHE
• Immunogen: Purified human cerebellar acetylcholinesterase.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rabbit, Bovine, Feline, Guinea Pig
• Product Type: Antibody
• Isotype: IgG2b

• Applications: ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immunocytochemistry
• Clone: HR2
• Conjugate: Unconjugated
• Gene: ACHE
• Gene Alias: ACE-1; ACEE; Acetylcholinesterase; acetylcholinesterase (Cartwright blood group); acetylcholinesterase (Yt blood group); acetylcholinesterase T-subunit; ACHE; ache protein; apoptosis-related acetylcholinesterase; ARACHE; EC 3.1.1.7; glycolipid-anchored form of acetylcholinesterase; N-ACHE; OTTHUMP00000211349; OTTHUMP00000211356; YT; Yt blood group; zgc:92550; ziehharmonika; zim
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 100009390, 100422792, 11423, 43, 493674, 540446
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid