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Invitrogen™ Acrosin Monoclonal Antibody (ACR-2)
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Catalog No. 01675950
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100 μg
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Catalog No. Quantity
01-675-950 100 μg
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Catalog No. 01-675-950 Supplier Invitrogen™ Supplier No. MA119180
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Description

Mouse Monoclonal Antibody

This antibody reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa), a typical serine proteinase with trypsin-like specificity. Acrosin is stored in the acrosome of undamaged spermatozoa. This antibody will not cross-react with human, canine or bovine. Immunocytochemistry: Membrane permeabilization (acetone) is essential.

ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Acrosin
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone ACR-2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene ACR
Gene Accession No. P08001
Gene Alias 53 kDa fucose-binding protein; Acr; Acro; Acrosin; Acrosin heavy chain; acrosin light and heavy chain prepropeptide; Acrosin light chain; acrosin precursor (EC 3.4.21.10); acrosin prepropeptide; ACRS; preproacrosin; proacrosin
Gene Symbols ACR
Host Species Mouse
Immunogen Acid extracts of boar spermatozoa were subjected to hydrophobic chromatography and the pooled fraction with reactivity to N-alpha benzoylarginine-4-nitroanilide was used for immunization.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 397098
Target Species Pig
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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