Invitrogen™ ACSL6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530465

Catalog No. PIPA530465

Description

Recommended positive controls: Jurkat, Raji, K562, THP-1, NCI-H929, mouse heart, rat heart. Predicted reactivity: Mouse (91%), Rat (89%), Rabbit (92%), Chimpanzee (100%), Bovine (93%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.

Specifications

• Antigen: ACSL6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Acsl6
• Gene Alias: A330035H04Rik; ACS2; ACSL6; acyl-CoA synthetase long-chain family member 6; Arachidonate--CoA ligase; AW050338; FACL6; fatty acid Coenzyme A ligase, long chain 6; fatty-acid-Coenzyme A ligase, long-chain 6; KIAA0837; L LACS5; LACS; LACS 6; LACS2; LACS5; Lacsl; long fatty acyl-CoA synthetase 2; long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase 6; long-chain-fatty-acid--CoA ligase, brain isozyme; mKIAA0837
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117243, 216739, 23305
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P33124, Q91WC3, Q9UKU0
• Gene Symbols: Acsl6
• Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human ACSL6. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov