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Invitrogen™ Actin Muscle Monoclonal Antibody (HHF35)
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Catalog No. PIMA110046
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100 μg
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PIMA110046 100 μg
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Catalog No. PIMA110046 Supplier Invitrogen™ Supplier No. MA110046
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Description

Mouse Monoclonal Antibody

This antibody recognizes muscle-specific alpha and gamma actin (42 kDa) in various species. This antibody stains skeletal, smooth and myocardial cells as well as myoepithelial cells and pericytes of small vessels. It is a widely used marker of muscle and muscle-derived cells. Western Blot: Reducing conditions; Immunohistochemistry (Paraffin): Antigen retrieval steps generally not required, but e.g. in case of arterial smooth muscle cells or myoepithelial cells, pepsin or trypsin pretreatment is recommended.

The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Actin Muscle
Applications Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone HHF35
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene ACTC1
Gene Accession No. P08023, P62736, P62737, P62738, P62740, P63259, P63260, P63261, P63267, P63268, P63269, P63270, P68032, P68033, P68034, P68035, P68133, P68134, P68135, P68136, P68139, Q5ZMQ2
Gene Alias 0610041G09Rik; AA959943; a-actin; AAT6; ACT; Act4; ACT-4; ACTA; ACTA1; ACTA1 protein; Acta2; Acta-2; ACTA3; ACTB; Actc; ACTC1; Actc-1; ACTE; Actg; Actg1; Actg2; ACTGE; actin; actin alpha 1; actin alpha 1, skeletal muscle; actin alpha 2, smooth muscle; actin alpha cardiac; actin alpha cardiac 1; actin alpha cardiac muscle 1; actin gamma 1; actin gamma 2, smooth muscle; actin homolog; actin, alpha 1, skeletal muscle; actin, alpha 2, smooth muscle, aorta; actin, alpha cardiac muscle 1; Actin, alpha cardiac muscle 1, intermediate form; Actin, alpha skeletal muscle; Actin, alpha skeletal muscle, intermediate form; actin, alpha, cardiac 1; actin, alpha, cardiac muscle; actin, alpha, cardiac muscle 1; actin, alpha, vascular smooth muscle; actin, aortic smooth muscle; Actin, aortic smooth muscle, intermediate form; actin, beta; actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; Actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1; actin, gamma 1 propeptide; actin, gamma 2; actin, gamma 2, smooth muscle, enteric; actin, gamma, cytoplasmic 1; actin, gamma-enteric smooth muscle; Actin, gamma-enteric smooth muscle, intermediate form; actin-like protein; Actl; ACTL3; Acts; ACTSA; Actsg; Actsk-1; Actvs; AL023024; alpha actin; alpha actin 1; alpha actin 2; alpha-actin; alpha-actin cardiac; alpha-actin-1; Alpha-actin-2; alpha-actin-3; alphac-actin; Alpha-cardiac actin; alphaSMA; alpha-sma; alpha-smooth muscle actin; ASD5; ASMA; a-SMA; B-actin; beta actin; beta-actin; beta-actin FE-3; BRWS2; cardiac actin; cardiac alpha actin; cardiac muscle alpha actin 1; cell growth-inhibiting gene 46 protein; CFTD; CFTD1; CFTDM; CMD1R; CMH11; cytoplasmic 2; cytoplasmic actin; cytoplasmic beta-actin; cytoplasmic type 5; cytoskeletal gamma-actin; deafness, autosomal dominant 20; deafness, autosomal dominant 26; DFNA20; DFNA26; E51; epididymis luminal protein 176; gamma 1 propeptide; gamma-2-actin; Gamma-actin; gamma-enteric smooth muscle actin; GIG46; HEL-176; hypothetical protein LOC515610; LOW QUALITY PROTEIN: actin, alpha skeletal muscle; LVNC4; MPFD; MYMY5; NEM1; NEM2; NEM3; nemaline myopathy type 3; RP5-1068B5.2; SHPM; similar to b-actin; skeletal alpha actin; skeletal muscle alpha-actin 1; SMalphaA; SMGA; smooth muscle alpha-actin; smooth muscle gamma-actin; type 5; unnamed protein product; vascular smooth muscle alpha-actin; VSCM
Gene Symbols ACTA1, ACTA2, ACTC1, ACTG1, ACTG2
Host Species Mouse
Immunogen SDS extracted protein fraction of human myocardium.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100009271, 100009506, 100144392, 100340339, 100350318, 101082743, 101093547, 101095439, 101095586, 11459, 11464, 11465, 11468, 11475, 25365, 287876, 29275, 29437, 396084, 415296, 421534, 423298, 423787, 475792, 475923, 477587, 478250, 488984, 58, 59, 70, 71, 72, 81633
Target Species Canine, Chicken, Feline, Human, Mouse, Monkey, Rabbit, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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