Actinomycin D

Description

CAS: 50-76-0 | C62H86N12O16 | 1255.438 g/mol

Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed RNA polymerase by complexing with DNA via deoxyguanosine residues. A DNA-intercalator with growth inhibitory activity against certain leukemias and sarcomas. At higher concentrations, DNA polymerase is inhibited. Inhibits cell growth and colony formation in synchronized HeLa cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Actinomycin D is used as an anti-neoplastic antibiotic. It is also used to inhibit RNA polymerase and is a potent inducer of apoptosis. It is also used as a potent antibiotic that binds to the GpC steps of DNA. Inhibits DNA-primed R

Specifications

Chemical Identifiers

• CAS: 50-76-0
• Molecular Formula: C62H86N12O16
• Molecular Weight (g/mol): 1255.438
• MDL Number: MFCD00005033
• InChI Key: RJURFGZVJUQBHK-HUZQGMAJSA-N
• Synonym: Dactinomycin; Actinomycin C1
• PubChem CID: 131954673
• IUPAC Name: 2-amino-4,6-dimethyl-3-oxo-1-N-[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-9-N-[(3R,6S,7R,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,
• SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

• Type: Actinomycin D
• Physical Form: Powder
• Melting Point: 251°C to 253°C
• Color: Orange to Red
• Quantity: 5 mg
• UN Number: UN3462
• Beilstein: 605235
• Merck Index: 14,2800
• Solubility Information: It is soluble ino 50 mM in DMSO.
• Formula Weight: 1255.4
• Chemical Name or Material: Actinomycin D

Safety and Handling

Hazard Category	H300-H336-H373
Hazard Statement	GHS H Statement H300-H360-H351 Fatal if swallowed. May damage fertility or the unborn child. Suspected of causing cancer.
Precautionary Statement	P260-P264b-P270-P271-P301+P310-P304+P340-P312-P314-P330-P501c
DOTInformation	Transport Hazard Class: 6.1; Packaging Group: II; Proper Shipping Name: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S.
EINECSNumber	200-063-6
RTECSNumber	AU1575000
TSCA	No
storageNote1	-30° to -10°C
Recommended Storage	Store at -20°C

SDS

RUO – Research Use Only