ACTL6B Polyclonal Antibody, Active Motif™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-3623	Active Motif 61692	10 μL
50-199-3622	Active Motif 61691	100 μL

Description

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.

Specifications

• Antigen: ACTL6B
• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: O94805
• Gene ID (Entrez): 51412
• Immunogen: This antibody was raised against a peptide within the N-terminal region of human ACTL6B.
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Gene: Actl6b

• Concentration: Lot-Specific
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
• Gene Alias: 53 kDa BRG1-associated factor B; actin like 6B; actin-like 6; actin-like 6B; Actin-like protein 6B; actin-like protein 6B {ECO:0000250; Actin-related protein Baf53b; Actl6; ACTL6B; actl6b {ECO:0000250; Arpna; ArpNalpha; ArpN-alpha; BAF53B; BRG1-associated factor 53B; hArpN alpha; UniProtKB:O94805}
• Gene Symbols: Actl6b
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody