ACTN4 Mouse anti-Human, Mouse, Rat, Clone: 1E12B8, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 666281IG150UL

Catalog No. 50-173-7046

Description

This antibody recognizes 105 kDa of endogenous ACTN4 protein in various lysates.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.

Specifications

• Antigen: ACTN4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: O43707, P57780, Q9QXQ0
• Gene Symbols: Actn4
• Immunogen: ACTN4 Fusion Protein Ag13549
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 1E12B8
• Conjugate: Unconjugated
• Gene: ACTN4
• Gene Alias: ACTININ 4, actinin, alpha 4, ACTN4, Alpha actinin 4, F actin cross linking protein, FSGS, FSGS1, Non muscle alpha actinin 4
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 60595, 63836, 81
• Content And Storage: -20°C
• Form: Liquid