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Invitrogen™ ACVR1B Monoclonal Antibody (4E1C1F12)
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Catalog No. PIMA530036
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Quantity:
100 μL
Catalog No. Quantity
PIMA530036 100 μL
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Catalog No. PIMA530036

Supplier: Invitrogen™ MA530036

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Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human ACVR1B/ALK-4.

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACVR1B
Applications ELISA
Classification Monoclonal
Clone 4E1C1F12
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene ACVR1B
Gene Accession No. P36896
Gene Alias 6820432J04; activin A receptor type 1B; activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; Activin receptor type-1B; activin receptor-like kinase 4; ACTRI; ActRIB; ActR-IB; ACVR1A; Acvr1b; ACVRLK2; ACVRLK4; ALK2; Alk4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
Gene Symbols ACVR1B
Host Species Mouse
Immunogen Recombinant Human ALK4 protein (Met1-Glu126).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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