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ADAM10 Mouse anti-Human, Clone: 2A6B7, Proteintech
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Catalog No. 501737038 Shop All Proteintech Group Inc Products
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50-173-7038 150 μL
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Catalog No. 50-173-7038 Supplier Proteintech Group Inc Supplier No. 666201IG150UL
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Description

Mouse Monoclonal Antibody

Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.

Specifications

Antigen ADAM10
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2A6B7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ADAM10
Gene Accession No. O14672
Gene Alias AD10, ADAM 10, ADAM10, CD156c, CDw156, HsT18717, kuz, Kuzbanian protein homolog, MADM
Gene Symbols ADAM10
Host Species Mouse
Immunogen ADAM10 Fusion Protein Ag23062
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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