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Invitrogen™ ADAM10 Polyclonal Antibody
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Catalog No. PIPA528161
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100 μL
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PIPA528161 100 μL
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Catalog No. PIPA528161 Supplier Invitrogen™ Supplier No. PA528161
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: THP-1. Predicted reactivity: Mouse (93%), Rat (94%), Xenopus laevis (89%), Pig (98%), Chicken (89%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADAM10
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.65 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Adam10
Gene Accession No. O14672, O35598
Gene Alias 1700031C13Rik; a disintegrin and metallopeptidase domain 10; a disintegrin and metalloprotease domain (ADAM) 10; a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; AD10; AD18; ADAM; ADAM 10; ADAM metallopeptidase domain 10; ADAM10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; HsT18717; KUZ; kuzbanian; kuzbanian protein homolog; MADM; Mammalian disintegrin-metalloprotease; metalloendopeptidases; metalloproteinase; myelin-associated metalloproteinase; RAK
Gene Symbols Adam10
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the Extracellular domain of human ADAM10. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 102, 11487
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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