Aflatoxin B1, crystalline, Thermo Scientific Chemicals

Catalog No.	Quantity
AC227340100	10 mg

Catalog No. AC227340100 Supplier Thermo Scientific Chemicals Supplier No. 227340100

Description

Aflatoxin B1, crystalline, CAS # 1162-65-8, is a member of a group of mycotoxins presenting potent hepatotoxic and carcinogenic activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Aflatoxin B1 (AFB1) is a member of a group of mycotoxins produced by Aspergillus flavus, and Aspergillus parasiticus showing carcinogenic activities
• AFB1 can induce the transversion of G to T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in a mutation and promoting the carcinogenic process

Applications

• Aflatoxin B1 shows teratogenic activity
• It is a CYP1A2, CYP2A6, CYP2D6, and CYP3A substrate and can be used to study the CYP family in in vitro and in vivo studies.
• It can cause immunosuppression in animal models.

Specifications

Chemical Identifiers

• CAS: 1162-65-8
• Molecular Formula: C17H12O6
• Molecular Weight (g/mol): 312.28
• MDL Number: MFCD00869647
• InChI Key: OQIQSTLJSLGHID-UHFFFAOYNA-N
• Synonym: aflatoxin b1, ccris 12, unii-9n2n2y55mh, afb1, 2,3,6aalpha,9aalpha-tetrahydro-4-methoxycyclopenta c furo 3',2':4,5 furo 2,3-h 1 benzopyran-1,11-dione, 1h,11h-cyclopenta c furo 3',2':4,5 furo 2,3-h 1 benzopyran-1,11-dione,2,3,6a,9a-tetrahydro-4-methoxy-, 6ar,9as, cyclopenta c furo 3',2':4,5 furo 2,3-h 1 benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy, cyclopenta c furo 3',2':4,5 furo 2,3-h 1 benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-4-methoxy-, 6ar,9as, aflatoxin-b1, aflatoxin b
• PubChem CID: 186907
• ChEBI: CHEBI:2504
• IUPAC Name: 11-methoxy-6,8,19-trioxapentacyclo[10.7.0.0²,⁹.0³,⁷.0¹³,¹⁷]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione
• SMILES: COC1=C2C3=C(C(=O)CC3)C(=O)OC2=C2C3C=COC3OC2=C1

• Packaging: Glass Bottle
• Quantity: 10 mg
• Merck Index: 15, 171
• Formula Weight: 312.27
• Chemical Name or Material: Aflatoxin B1

Safety and Handling

Hazard Category	Danger
Hazard Statement	GHS H Statement: Fatal if inhaled. May cause cancer. Fatal in contact with skin.
Precautionary Statement	GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection. Remove/Take off immediately all contaminated clothing. IF ON SKIN: Gently wash with plenty of soap and water. Immediately call a POISON CENTER or doctor/physician. Obtain special instructions before use. IF exposed or concerned: Get medical advice/attention. IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
EINECSNumber	214-603-3
RTECSNumber	GY1925000

SDS

RUO – Research Use Only