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Invitrogen™ AFP Monoclonal Antibody (AFP-11)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA119342

Catalog No. 01-676-098


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Description

Description

This antibody reacts with human alpha-Fetoprotein (AFP), a 70 kDa oncofetal antigen. AFP is a major fetal plasma protein, but is not present in healthy adult tissues. Elevated AFP concentrations in adult plasma may be an early marker of hepatocellular carcinoma or teratoblastoma, while high concentrations in amniotic fluid may indicate severe congenital defects of a fetus. The MA1-19342 anti-alpha Fetoprotein antibody (clone AFP-11) has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody MA1-19178 (clone AFP-01). Immunohistochemistry (Paraffin): Heat mediated antigen retrieval (sodium citrate buffer); mAb incubation 1 hour / RT, detection DAB; Western Blot: non-reducing conditions.

AFP (Alpha Fetoprotein) is a major plasma protein produced by the yolk sac, intestinal tract and the liver during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of AFP may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric, dimeric, and trimeric forms. AFP can also bind to copper ions, nickel ions, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. High level of serum AFP has been identified in patients with hepatocellular carcinomas (HCC), teratoblastoma, colorectal cancer, pancreatic cancer, and germ cell neoplasms.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

AFP
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P02771
AFP
Purified alpha Fetoprotein.
100 μg
Primary
Human
Antibody
IgG1
ELISA, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot, Immunocytochemistry
AFP-11
Unconjugated
AFP
a fetoglobulin; a fetoprotein; Afp; AFPD; Alpha fetoglobulin; alpha fetoprotein; alpha-1-fetoprotein; Alpha-fetoglobulin; alpha-fetoprotein; alpha-fetoprotein precursor; alpha-foetoprotein; chloride intracellular channel 6; FETA; fetoglobulin; fetoprotein; HPAFP; a fetoglobulin; a fetoprotein
Mouse
Protein A
RUO
174
4°C, do not freeze
Liquid
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