Apexbio Technology LLC AHU-377 hemicalcium salt 1369773-39-6 10mg

Supplier:  Apexbio Technology LLC B326710

AHU-377 hemicalcium salt (CAS 1369773-39-6) is a hemicalcium salt form of AHU-377 a potent inhibitor of neprilysin (neutral endopeptidase) with an IC50 of 5 nM As a prodrug AHU-377 is enzymatically converted to its active metabolite LBQ657 following ester cleavage AHU-377 is a key component of LCZ696 co-formulated with valsartan at a 1 1 molar ratio functioning as an angiotensin receptor neprilysin inhibitor (ARNI) In vivo studies demonstrate that oral administration of AHU-377 induces dose-dependent blood pressure reduction in DAHI-SS rats though it has less pronounced effects in DOCA-salt hypertensive models AHU-377 is widely studied in cardiovascular research particularly in the context of heart failure and hypertension

Catalog No. 50-000-94733