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AKAP13 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 279471AP150UL

Encompass_Preferred

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Catalog No. 50-173-5790


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Description

Description

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.
Specifications

Specifications

AKAP13
Polyclonal
Unconjugated
AKAP13
A kinase anchor protein 13, AKAP 13, AKAP Lbc, AKAP13, ARHGEF13, BRX, c lbc, HA 3, Ht31, LBC, LBC oncogene, Lymphoid blast crisis oncogene, p47, PROTO LB, PROTO LBC
Rabbit
Antigen Affinity Chromatography
RUO
11214
-20°C
Liquid
Immunohistochemistry (Paraffin)
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q12802
AKAP13
AKAP13 Fusion Protein Ag27486
150 μL
Primary
Human
Antibody
IgG
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