AKAP13 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-5790	150 μL

Catalog No. 50-173-5790 Supplier Proteintech Group Inc Supplier No. 279471AP150UL

Description

Rabbit Polyclonal Antibody

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

Specifications

• Antigen: AKAP13
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.33 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: AKAP13
• Gene Accession No.: Q12802
• Gene Alias: A kinase anchor protein 13, AKAP 13, AKAP Lbc, AKAP13, ARHGEF13, BRX, c lbc, HA 3, Ht31, LBC, LBC oncogene, Lymphoid blast crisis oncogene, p47, PROTO LB, PROTO LBC
• Gene Symbols: AKAP13
• Host Species: Rabbit
• Immunogen: AKAP13 Fusion Protein Ag27486
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11214
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG