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Invitrogen™ Akirin2 Polyclonal Antibody
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Catalog No. PIPA534875
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100 μL
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PIPA534875 100 μL
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Catalog No. PIPA534875 Supplier Invitrogen™ Supplier No. PA534875
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, HeLa, HCT116. Predicted reactivity: Mouse (95%), Rat (95%), Zebrafish (81%), Xenopus laevis (83%), Pig (98%), Chicken (94%), Sheep (97%), Chimpanzee (100%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Akirin2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene AKIRIN2
Gene Accession No. Q53H80
Gene Alias 14-3-3 beta; 2700059D21Rik; AA114675; AA522011; akirin 2; Akirin2; Akirin-2; akirin2 {ECO:0000250; AU019887; C6orf166; dJ486L4.2; EMBL:BAE81786.1}; FBI1; Fourteen-three-three beta interactant 1; fourteen-three-three beta interactant 1 {ECO:0000312; fourteen-three-three beta interacting-protein 1; RGD1307791; UniProtKB:Q53H80}
Gene Symbols AKIRIN2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Akirin 2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55122
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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