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Tocris Bioscience™ AKOS 022

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Quantity:
10 mg
50 mg
Description
AKOS 022 is a voltage-dependent anion channel (VDAC; Kd = 154 μM) inhibitor, which reduces channel conductance. In HEK-293 cells, AKOS 022 inhibits selenium-induced VDAC oligomerization, cytochrome C release from mitochondria and apoptosis (IC50 values range from 3.3 to 3.6 μM). AKOS 022 also prevents glucotoxicity-mediated overexpression of VDAC1 in INS-1 cells.
Specifications
Specifications
Chemical Name or Material | 1-(4-Chlorophenyl)-3-[4-[[4-(trifluoromethoxy)phenyl]amino]-1-piperidinyl]-2,5-pyrrolidinedione |
CAS | 878983-38-1 |
Quantity | 50 mg |
Target | Ion Channel Modulators |
Molecular Formula | C22H21ClF3N3O3 |
Purity | 0.98 |
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