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Invitrogen™ AKR1B10 Polyclonal Antibody
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Catalog No. PIPA522036
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100 μL
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PIPA522036 100 μL
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Catalog No. PIPA522036 Supplier Invitrogen™ Supplier No. PA522036
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Molt-4, Raji, mouse colon, rat colon, Jurkat, NCI-H929. Predicted reactivity: Mouse (82%), Rat (82%), Rabbit (86%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

AKR1B10, a 316aa protein, catalyzes efficient reduction ofaliphatic and aromatic aldehydes. It the first cytosolic NADP (H)-dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications.It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AKR1B10
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene Akr1b10
Gene Accession No. O60218
Gene Alias 2310005E10Rik; AKR1B10; AKR1B11; AKR1B12; Akr1b16; aldo-keto reductase family 1 member B10; aldo-keto reductase family 1, member B10; aldo-keto reductase family 1, member B10 (aldose reductase); aldo-keto reductase family 1, member B11 (aldose reductase-like); Aldose reductase-like; aldose reductase-like 1; aldose reductase-like peptide; aldose reductase-related protein; ALDRLn; ARL1; ARL-1; ARP; hARP; HIS; HSI; MGC14103; SI reductase; small intestine reductase
Gene Symbols Akr1b10
Host Species Rabbit
Immunogen Full length human AKR1B10 Recombinant protein.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 296972, 57016, 67861
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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