Invitrogen™ AKR1C1/AKR1C2 Polyclonal Antibody

Catalog No.	Quantity
PIPA578752	100 μg

Catalog No. PIPA578752 Supplier Invitrogen™ Supplier No. PA578752

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HepG2 whole cell, human A549 whole cell, human HCCP tissue, rat liver tissue, rat kidney tissue, mosue liver tissue, mosue kidney tissue. ICC/IF: HepG2 cell. Flow: HepG2 cell.

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. And this gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: AKR1C1/AKR1C2
• Applications: Flow Cytometry, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: AKR1C1
• Gene Accession No.: P52895, Q04828, Q6AYQ2
• Gene Alias: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); 20-ALPHA-HSD; 20-alpha-hydroxysteroid dehydrogenase; 2-ALPHA-HSD; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; 3-alpha-hydroxysteroid dehydrogenase; AKR1C1; Akr1c2; Akr1c21; Akr1c6; AKR1C-pseudo; aldo-keto reductase C; aldo-keto reductase family 1 member C1; Aldo-keto reductase family 1 member C2; aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase); aldo-keto reductase family 1, member C2; aldo-keto reductase family 1, member C21; aldo-keto reductase family 1, member C6; BABP; C9; chlordecone reductase homolog HAKRC; Chlordecone reductase homolog HAKRD; DD; DD/BABP; DD1; DD1/DD2; DD2; DD-2; DDH; DDH1; DDH2; dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; Dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; dihydrodiol dehydrogenase isoform DD1; Dihydrodiol dehydrogenase/bile acid-binding protein; H-37; HAKRC; HAKRD; HBAB; hepatic dihydrodiol dehydrogenase; high-affinity hepatic bile acid-binding protein; Hsd17b5; Indanol dehydrogenase; MBAB; MCDR2; pseudo-chlordecone reductase; SRXY8; TDD; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type 5 17beta-hydroxysteroid dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase
• Gene Symbols: AKR1C1, Akr1c2
• Host Species: Rabbit
• Immunogen: E. coli-derived human AKR1C1/C2 recombinant protein (Position: M1-K123).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1645, 1646, 291283, 307092
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov