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AKT Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech
SDP

Catalog No. 501726083 Shop All Proteintech Group Inc Products
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50-172-6083 150 μL
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Catalog No. 50-172-6083 Supplier Proteintech Group Inc Supplier No. 101762AP150UL
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Description

Rabbit Polyclonal Antibody

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Specifications

Antigen AKT
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene AKT1
Gene Accession No. P31749, P31750, P31751, P47196, P47197, Q60823, Q63484, Q9WUA6, Q9Y243
Gene Alias AKT, AKT1, AKT2, AKT3, PKB, PKB ALPHA, PRKBA, Protein kinase B, Proto oncogene c Akt, RAC, RAC ALPHA, RAC PK alpha
Gene Symbols akt1, akt2, Akt3, akt3a
Host Species Rabbit
Immunogen AKT Fusion Protein Ag0213
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10000, 101910198, 11651, 11652, 207, 208, 23797, 24185, 25233, 29414, 378972, 560549
Target Species Human, Mouse, Rat, Zebrafish
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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