ALAS1 Monoclonal Antibody (OTI1C5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808177

Catalog No. 50-168-1950

Description

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5′ phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.

Specifications

• Antigen: ALAS1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P13196
• Gene Symbols: ALAS1
• Immunogen: Human recombit protein fragment corresponding to amino acids 57-308 of human ALAS1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI1C5
• Conjugate: Unconjugated
• Gene: ALAS1
• Gene Alias: ALAS, ALAS-H, ALAS3, ALASH, MIG4
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 211
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid