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ALAS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 162001AP

Catalog No. 50-173-0785


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Description

Description

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5 ft. phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
Specifications

Specifications

ALAS1
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P13195, P13196, Q8VC19
ALAS, ALAS H, ALAS1, ALAS3, ALASH, Delta ALA synthase 1, MIG4
Rabbit
IgG
150 μL
-20°C
Primary
11655, 211, 65155
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
ALAS1
Liquid
Alas1
ALAS1 Fusion Protein Ag9126
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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