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Invitrogen™ ALK Monoclonal Antibody (SP8)
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Catalog No. PIMA514528
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500 μL
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PIMA514528 500 μL
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Catalog No. PIMA514528 Supplier Invitrogen™ Supplier No. MA514528
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Description

Rabbit Monoclonal Antibody

MA5-14528 targets ALK (Anaplastic Lymphoma Kinase) / p80 in IHC (P) and ICC/IF applications and shows reactivity with Human and Mouse samples. The MA5-14528 immunogen is recombinant protein corresponding to a region, which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript.

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ALK
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Monoclonal
Clone SP8
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Tissue culture supernatant, TBS with 1% BSA and 0.1% sodium azide; pH 7.5
Gene ALK
Gene Accession No. P97793, Q9UM73
Gene Alias Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK
Gene Symbols ALK
Host Species Rabbit
Immunogen Recombinant fragment within ALK aa 1350-1500. The exact sequence is proprietary.
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11682, 238
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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